AustralieFrV1, Main, Exploration, bibRecord, 008F93

Mapping MHC-Resident Transplantation Determinants

Identifieur interne : 008F93 ( Main/Exploration ); précédent : 008F92; suivant : 008F94

Mapping MHC-Resident Transplantation Determinants

Auteurs : Mari Malkki [États-Unis] ; Ted A. Gooley [États-Unis] ; Mary M. Horowitz [États-Unis] ; Lena Absi [France] ; Frank T. Christiansen [Australie] ; Jan J. Cornelissen [Pays-Bas] ; Anne Dormoy [France] ; Valerie Dubois [France] ; Katia Gagne [France] ; Eliane Gluckman [France] ; Michael D. Haagenson [États-Unis] ; Machteld Oudshoorn [Pays-Bas] ; Stephen Spellman [États-Unis] ; Effie W. Petersdorf [États-Unis]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2007.

RBID : PMC:3182140

Abstract

Graft-versus-host disease (GVHD) accounts for increased morbidity and mortality after HLA-identical unrelated hematopoietic cell transplantation (HCT). To test the hypothesis that the MHC encodes functional variation other than the classical HLA genes, we measured risks associated with donor-recipient MHC microsatellite (Msat) marker mismatching in 819 HCT recipients and their HLA-A, -B, -C, -DRB1, -DQB1 allele-matched unrelated donors. Suggestive trends of association with transplant outcome were observed for five Msats. Donor-recipient mismatching for the extended class I D6S105, class III D6S2787 and class II D6S2749 markers was each associated with an increased risk of death (hazard ratio, 1.32; 95% confidence interval, 1.02–1.71; P = .03; hazard ratio, 1.26; 95% confidence interval, 1.03–1.53; P = .02; hazard ratio, 1.37; 95% confidence interval, 1.08–1.72; P = .007, respectively) whereas mismatching for the class I D6S2811 marker was associated with a decreased risk of death (hazard ratio, 0.80; 95% confidence interval, 0.66–0.98; P = .03). Mismatching for the class I D6S265 marker was associated with a decreased risk of grades III-IV acute GVHD (odds ratio, 0.67; 95% confidence interval, 0.45–0.98; P = .04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182140

DOI: 10.1016/j.bbmt.2007.05.007
PubMed: 17640603
PubMed Central: 3182140

Affiliations:

Le document en format XML

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<author><name sortKey="Cornelissen, Jan J" sort="Cornelissen, Jan J" uniqKey="Cornelissen J" first="Jan J." last="Cornelissen">Jan J. Cornelissen</name>
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<author><name sortKey="Dormoy, Anne" sort="Dormoy, Anne" uniqKey="Dormoy A" first="Anne" last="Dormoy">Anne Dormoy</name>
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<author><name sortKey="Dubois, Valerie" sort="Dubois, Valerie" uniqKey="Dubois V" first="Valerie" last="Dubois">Valerie Dubois</name>
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<author><name sortKey="Gagne, Katia" sort="Gagne, Katia" uniqKey="Gagne K" first="Katia" last="Gagne">Katia Gagne</name>
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<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
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<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<author><name sortKey="Haagenson, Michael D" sort="Haagenson, Michael D" uniqKey="Haagenson M" first="Michael D." last="Haagenson">Michael D. Haagenson</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Minnesota</region>
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<author><name sortKey="Oudshoorn, Machteld" sort="Oudshoorn, Machteld" uniqKey="Oudshoorn M" first="Machteld" last="Oudshoorn">Machteld Oudshoorn</name>
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<placeName><settlement type="city">Leyde</settlement>
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<author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Minnesota</region>
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<author><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
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<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Graft-versus-host disease (GVHD) accounts for increased morbidity and mortality after HLA-identical unrelated hematopoietic cell transplantation (HCT). To test the hypothesis that the MHC encodes functional variation other than the classical HLA genes, we measured risks associated with donor-recipient MHC microsatellite (Msat) marker mismatching in 819 HCT recipients and their HLA-A, -B, -C, -DRB1, -DQB1 allele-matched unrelated donors. Suggestive trends of association with transplant outcome were observed for five Msats. Donor-recipient mismatching for the extended class I D6S105, class III D6S2787 and class II D6S2749 markers was each associated with an increased risk of death (hazard ratio, 1.32; 95% confidence interval, 1.02–1.71; <italic>P</italic>
 = .03; hazard ratio, 1.26; 95% confidence interval, 1.03–1.53; <italic>P</italic>
 = .02; hazard ratio, 1.37; 95% confidence interval, 1.08–1.72; <italic>P</italic>
 = .007, respectively) whereas mismatching for the class I D6S2811 marker was associated with a decreased risk of death (hazard ratio, 0.80; 95% confidence interval, 0.66–0.98; <italic>P</italic>
 = .03). Mismatching for the class I D6S265 marker was associated with a decreased risk of grades III-IV acute GVHD (odds ratio, 0.67; 95% confidence interval, 0.45–0.98; <italic>P</italic>
 = .04). These results suggest that Msats may be informative for mapping MHC-resident genetic variation of clinical importance in HCT.</p>
</div>
</front>
</TEI>
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<name sortKey="Gooley, Ted A" sort="Gooley, Ted A" uniqKey="Gooley T" first="Ted A." last="Gooley">Ted A. Gooley</name>
<name sortKey="Haagenson, Michael D" sort="Haagenson, Michael D" uniqKey="Haagenson M" first="Michael D." last="Haagenson">Michael D. Haagenson</name>
<name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
<name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
<name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
</country>
<country name="France"><noRegion><name sortKey="Absi, Lena" sort="Absi, Lena" uniqKey="Absi L" first="Lena" last="Absi">Lena Absi</name>
</noRegion>
<name sortKey="Dormoy, Anne" sort="Dormoy, Anne" uniqKey="Dormoy A" first="Anne" last="Dormoy">Anne Dormoy</name>
<name sortKey="Dubois, Valerie" sort="Dubois, Valerie" uniqKey="Dubois V" first="Valerie" last="Dubois">Valerie Dubois</name>
<name sortKey="Gagne, Katia" sort="Gagne, Katia" uniqKey="Gagne K" first="Katia" last="Gagne">Katia Gagne</name>
<name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
</country>
<country name="Australie"><noRegion><name sortKey="Christiansen, Frank T" sort="Christiansen, Frank T" uniqKey="Christiansen F" first="Frank T." last="Christiansen">Frank T. Christiansen</name>
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<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Cornelissen, Jan J" sort="Cornelissen, Jan J" uniqKey="Cornelissen J" first="Jan J." last="Cornelissen">Jan J. Cornelissen</name>
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<name sortKey="Oudshoorn, Machteld" sort="Oudshoorn, Machteld" uniqKey="Oudshoorn M" first="Machteld" last="Oudshoorn">Machteld Oudshoorn</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008F93 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008F93 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3182140
   |texte=   Mapping MHC-Resident Transplantation Determinants
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:17640603" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Mapping MHC-Resident Transplantation Determinants

Mapping MHC-Resident Transplantation Determinants

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.